Prevalence and mortality of infective endocarditis among community acquired and healthcare acquired staphylococcus aureus bacteremia: a nationwide study

Abstract Background Staphylococcus aureus bacteremia (SAB) may be community acquired or healthcare acquired, and prior small studies have suggested that the place of acquisition impacts subsequent prevalence infective endocarditis (IE) also patient outcomes. However, data on this relationship is sparse influence optimal work-up treatment these patients. Purpose To examine IE among patients with SAB. Further, to investigate one-year mortality SAB-IE stratified by acquisition. Methods Patients first-time SAB from 2010–2018 were identified using Danish nationwide registries categorized into either (no health care contact within 30 days) (either a. hospital admission emergency room visit days, b. >48 hours after admission, c. out-patient dialysis). was then related compared between two study groups multivariable adjusted logistic regression analysis. The Cox proportional hazard analysis for assumption violated, a landmark conducted comparing a) 0–40 days follow-up, b) 40–365 follow-up. Results We 13,040 SAB; 5,512 (62.3% male, median age 71.0 years) 7,528 (63.1% 69.0 acquired. 12.0% 6.6% SAB, Figure. After accounting characteristics, associated higher odds as OR=2.12 (95% CI: 1.86–2.41). Sex- did not modify association. 37.3% 47.3% SAB-IE, With up 40 no difference in seen analysis, HR=1.07 0.83–1.37) reference group. Beyond follow-up lower HR=0.71 0.53–0.95). Conclusion Community twice high rates, at short-term however long-term revealed an SAB-IE. These findings indicate need intensified strategy Funding Acknowledgement Type funding sources: None.